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Alfacalcidol je aktivní metabolit vitamínu D, který má důležitou funkci v regulaci rovnováhy vápníku a kostního metabolismu. Alfacalcidol je analog hormonu vitaminu D, který je aktivován enzymem 25-hydroxylázy v játrech pro systémové a lokální působení osteoblastů D-hormonu. Má jedinečný pleiotropní účinek na, např. střeva, kosti, příštítná tělíska, svaly a mozek. Alfacalcidol je lepší než obyčejný vitamin D (cholekalciferol), protože u obyčejného vitaminu D konečná aktivace funkce ledvin je regulována mechanismem negativní zpětné vazby. Ačkoli alfacalcidol je široce používán k léčbě osteoporózy, mechanismus jeho účinku v kostech není zcela objasněn. Alfacalcidol stimuluje střevní absorpci vápníku (Ca), zvyšuje vylučování Ca močí a sérovou hladinu Ca a potlačuje vylučování hormonu parathormonu (PTH). Výrobce: Macleods Onemocnění: Osteoporosis / Hypocalcemia / Hypophosphatemia / Osteodystrophy / Rickets / Prophylaxis / Secondary Hyperparathyroidism / Tetany / Vitamin D Deficiency /
Nejprodávanější množství. One-alpha capsulesWhat is this product?Alfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. Alfacalcidol is Vitamin D-hormone analog which is activated by the enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone actions. It possesses a unique pattern of pleiotropic effects on, e.g. gut, bone, pararthyroids, muscle and brain. Alfacalcidol is superior to plain vitamin D (cholecalciferol) because the final kidney activation of the latter is regulated by a negative feedback mechanism. Although alfacalcidol is widely used in the treatment of osteoporosis, its mechanism of action in bone is not fully understood. Alfacalcidol stimulates intestinal calcium (Ca) absorption, increases urinary Ca excretion and serum Ca levels, and suppresses parathyroid hormone (PTH) secretion. What indications has this product?One-Alpha is indicated in all conditions where there is a disturbance of calcium metabolism due to impaired 1-α hydroxylation such as when there is reduced renal function. The main indications are:
How should I take this product?Take it exactly as it's been prescibed by your doctor. It comes as a capsule to take by mouth, with food. ContraindicationsHypersensitivity to the active substance or to any of the excipients, hypercalcaemia, metastatic calcification. What should you know before using this medication?During treatment with One-Alpha, serum calcium and serum phosphate levels should be monitored regularly especially in children, patients with renal impairment and patients receiving high doses. PTH, alkaline phosphatase and calcium phosphates should be monitored as clinically indicated. PregnancyThere is a limited amount of data from the use of alfacalcidol in pregnant women. Studies in animals have shown reproductive toxicity at high doses. Therefore, One-Alpha is not recommended during pregnancy and in women of child-bearing potential not using contraception. Breast-feedingAlthough it has not been established, it is likely that increased amounts of 1,25-dihydroxyvitamin D will be found in the milk of lactating mothers treated with One-Alpha. This may influence calcium metabolism in the infant. Consequently, breast-fed infants of alfacalcidol-using mothers should be monitored closely for hypercalcaemia. FertilityThere are no clinical studies on the effect of One-Alpha on fertility. A pre-clinical study did not show an effect on fertility in rats. What are the posible side effects?
Effects on ability to drive and use machinesAlfacalcidol has no or negligible direct influence on the ability to drive and use machines. However, the patient should be informed that dizziness may occur during treatment and take this into account while driving or using machines. What should I know in case of an overdose?Excessive intake of One-Alpha may lead to the development of hypercalcaemia, however, the effect is reversed rapidly on withdrawal. In severe cases of hypercalcaemia general supportive measures should be undertaken. Keep the patient well hydrated by i.v. infusion of saline (force diuresis), measure electrolytes, calcium and renal function indices, assess electrocardiographic abnormalities, especially in patients using digitalis. More specifically, treatment with glucocorticosteroids, loop diuretics, bisphosphonates, calcitonin and eventually haemodialysis with low calcium content should be considered. What are the storage conditions for Alfacalcidol?Capsules: Store it at room temperature (25°C), and in an airtight container. |
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